Fri Dec 09 2022

53 articles - From Friday Dec 02 2022 to Friday Dec 09 2022

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Lancet

STRONG start for implementation of guideline-directed medical therapies.

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Meta-analysis

meta-analyses and systematic reviews


Original articles

RCT, clinical trials, retrospective studies, etc…

Ann Intern Med

BP-lowering drugs reduced major CV events by similar amounts in patients with and without type 2 diabetes.

2022; 10:645-54. 35878651.

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Comparative Effectiveness of Team-Based Care With and Without Clinical Decision Support System for Diabetes Management : A Cluster Randomized Trial.

Compared with team-based care alone, team-based care with a CDSS significantly reduced cardiovascular risk factors in patients with diabetes, but the effect was modest. Primary funding source Xiamen Municipal Health Commission.

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Effects of Dapagliflozin on Hospitalizations in Patients With Chronic Kidney Disease : A Post Hoc Analysis of DAPA-CKD.

Dapagliflozin reduced the risk for hospitalization for any cause in patients with CKD with and without type 2 diabetes. Primary funding source AstraZeneca.

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In acute decompensated HF, adding acetazolamide to IV loop diuretics reduced congestion at 3 d.

2022; 387:1185-95. 36027559.

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In adults, risk for infective endocarditis varied for invasive dental procedures and by antibiotic prophylaxis.

2022; 80:1029-41. 35987887.

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In CV disease, clopidogrel reduces nonfatal MI and MACE vs. aspirin but not stroke or mortality.

2022; 122:1879-87. 35577054.

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In generally healthy adults, supplemental vitamin D3 did not reduce fractures vs. placebo at 5 y.

2022; 387:299-309. 35939577.

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In ischemic left ventricular systolic dysfunction, adding PCI to medical therapy did not reduce death or HF hospitalization.

2022; 387:1351-60. 36027563.

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In monkeypox, risk for some symptoms was greater in MSM with vs. without receptive anal contact.

2022; 400:661-9. 35952705.

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In older men, an invitation for comprehensive CV screening did not reduce death at 5.6 y.

2022; 387:1385-94. 36027560.

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In THA or TKA, risk for symptomatic VTE was higher with aspirin vs. enoxaparin at 90 d.

2022; 328:719-27. 35997730.

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In the general population, salt substitutes vs. regular salt reduce BP levels, CV outcomes, and mortality.

2022; 108:1608-15. 35945000.

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Long-Term Stability of Coverage Among Michigan Medicaid Beneficiaries : A Cohort Study.

For many beneficiaries, Medicaid has served as their primary source of coverage for at least a decade. This pattern would justify increasing investments in the program to improve long-term health outcomes. Primary funding source Self-funded.

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N Engl J Med

Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus.

Expectant management for PDA in extremely premature infants was noninferior to early ibuprofen treatment with respect to necrotizing enterocolitis, bronchopulmonary dysplasia, or death at 36 weeks' postmenstrual age. (Funded by the Netherlands Organization for Health Research and Development and the Belgian Health Care Knowledge Center; BeNeDuctus ClinicalTrials.gov number, NCT02884219; EudraCT number, 2017-001376-28.).

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Prostate Cancer Screening with PSA and MRI Followed by Targeted Biopsy Only.

The avoidance of systematic biopsy in favor of MRI-directed targeted biopsy for screening and early detection in persons with elevated PSA levels reduced the risk of overdiagnosis by half at the cost of delaying detection of intermediate-risk tumors in a small proportion of patients. (Funded by Karin and Christer Johansson's Foundation and others; GÖTEBORG-2 ISRCTN Registry number, ISRCTN94604465.).

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Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma.

In patients with advanced melanoma, progression-free survival was significantly longer among those who received TIL therapy than among those who received ipilimumab. (Funded by the Dutch Cancer Society and others; ClinicalTrials.gov number, NCT02278887.).

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Lancet

Lecanemab for Alzheimer's disease: tempering hype and hope.

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Offline: FRENCH-ARRIVE-elles accusent.

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N Engl J Med

Audio Interview: Covid-19 and Health Equity.

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Reducing Prostate Cancer Overdiagnosis.

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TIL Therapy Entering the Mainstream.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Ann Intern Med

Annals On Call - Procalcitonin Revisited.

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Summary for Patients: Effects of Dapagliflozin on Hospitalizations in Patients With Chronic Kidney Disease.

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The Stability and Continuity of Medicaid Coverage.

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Lancet

A missed opportunity? Anopheles stephensi in Africa.

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Cholera surges in Haiti.

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Concern after Mali bans French NGOs.

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Monkeypox virus infection in women and non-binary people: uncommon or neglected?

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Mummies, myths, and medicine in ancient Egypt.

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Oncology at CERN: accelerating radiotherapy.

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Subacute parkinsonism due to systemic lupus erythematosus and catastrophic antiphospholipid syndrome.

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N Engl J Med

A Rural Idyll.

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Case 37-2022: A 55-Year-Old Man with Fatigue, Weight Loss, and Pulmonary Nodules.

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Closing the Gap in Cancer Genomic Testing.

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Deciding on My Dimples.

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Filarial Dance Sign in Lymphatic Filariasis of the Scrotum.

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For-Profit Medical Schools - Concerns about Quality and Oversight.

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Reverse Isotopic Response.

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Venkamma's Dowry.

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Letters&Replies

Letters to the editors and authors’ replies

Lancet

Ebola outbreak in Uganda: patient values and preferences.

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Integrated respiratory surveillance after the COVID-19 pandemic.

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Weaponisation of water.

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N Engl J Med

Aggressive or Moderate Fluids in Acute Pancreatitis.

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Aggressive or Moderate Fluids in Acute Pancreatitis.

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Aggressive or Moderate Fluids in Acute Pancreatitis.

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Aggressive or Moderate Fluids in Acute Pancreatitis. Reply.

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Breakthrough Infections after Postexposure Vaccination against Mpox.

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Efficacy of Antiviral Agents against Omicron Subvariants BQ.1.1 and XBB.

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Polypill Strategy in Secondary Cardiovascular Prevention.

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Polypill Strategy in Secondary Cardiovascular Prevention.

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Polypill Strategy in Secondary Cardiovascular Prevention.

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Polypill Strategy in Secondary Cardiovascular Prevention. Reply.

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